The Remarkable Benefits of Low-Dose Naltrexone

This article was beforehand revealed December 13, 2020, and has been up to date with new information.

In this interview, we assessment some of the outstanding advantages of low-dose naltrexone (LDN), together with the stunning advantages of microdosed LDN. The two specialists featured on this interview are Linda Elsegood, a Briton who based the LDN Research Trust1 in 2004, and Dr. Sarah Zielsdorf, who has a medical observe within the Chicago space within the U.S.

Elsegood, who was identified with MS in 2000, has been concerned in LDN analysis and public training for 16 years. LDN is a strong, secure and efficient therapy for a lot of autoimmune illnesses, but few, together with most well being care professionals, know something about it. Remarkably, LDN might even be useful within the battle in opposition to COVID-19, because it acts to normalize your immune system.2

Elsegood not too long ago revealed a ebook on LDN referred to as “The LDN Book, Volume Two: The Latest Research on How Low Dose Naltrexone Could Revolutionize Treatment for PTSD, Pain, IBD, Lyme Disease, Dermatologic Conditions and More.” Each chapter is written by a medical skilled with medical information of the drug’s use. Zielsdorf is one of the contributing authors. Elsegood additionally hosts a radio present referred to as The LDN Radio Show.3

In the interview, she tells the story of how she found LDN and the dramatic advantages she has skilled from it. In abstract, helpful results turned obvious after about three weeks on the drug and, after 18 months, her situation had considerably improved.

Zielsdorf — who has an undergraduate diploma in microbiology and a grasp’s diploma in public well being microbiology and rising infectious illness — additionally has a private well being story that introduced her to LDN. She was identified with hypothyroidism (underactive thyroid) in 2003. Ten years later, she was identified with Hashimoto’s, an autoimmune dysfunction that impacts the thyroid.

“I realized about purposeful vitamin and triggers for autoimmunity, and began to do all of the issues I wanted to do to optimize my biomarkers, take away systemic irritation, and was in a position to return to my [medical] coaching. I had been informed that I may by no means have youngsters and surprisingly turned pregnant and had a daughter in my second 12 months of coaching.

After having her, I [had a flareup]. It was then, in 2014, that a physician put me on LDN. It modified my life … Once I graduated from residency, I began treating sufferers with a range of points with LDN. I’ve handled hundreds of sufferers with LDN.”

Naltrexone — A Rare Gem of a Drug

Naltrexone in low and even microdoses is one of the few pharmaceutical medication I wholeheartedly endorse. Not solely is it remarkably secure, it is also a profound adjunctive remedy for all kinds of circumstances. As defined by Zielsdorf:

“Naltrexone is one of the few issues that really permits our personal our bodies, our personal immune methods, to have the ability to operate higher and actually restore operate.

After World War II, they have been searching for extra opioid medicines. By accident, scientists found out tips on how to block the opioid receptor. They did the precise reverse of what they have been purported to do, which is to seek out morphine analogs for troopers.

[In] the Sixties, they have been in a position to synthesize naloxone and naltrexone … FDA authorised it within the Eighties for opioid habit at a dose of 50 to 100 milligrams, after which within the Nineteen Nineties for alcohol dependence.

But it was Dr. Bernard Bihari and Dr. Ian Zagon within the Seventies that had this wonderful concept that in the event you took a really small dose of naltrexone, compounding it in a clear method [down] to some milligrams, if would briefly block the opioid receptor within the central nervous system — very briefly kissing that receptor after which unblocking it.

This upregulates the physique’s immune system by growing the opioid receptor’s personal manufacturing of beta-endorphin and met-enkephalins. Beta-endorphins assist with temper, ache, sleep and the immune system, and met-enkephalins are often known as opioid-derived development issue, and there are receptors for these on many alternative tissues, together with the thyroid.

We now use it for practically all autoimmune circumstances, as an adjunct for most cancers, and as a therapy for continual ache. We additionally use ultra-low dose [microdosed] naltrexone, which I wrote about, to assist potentiate ache reduction for people who find themselves on opioids and assist them to be much less depending on opioid medicines.

I’ve truly been in a position to get sufferers off of fentanyl patches and get them off continual oxycodone or Norco use the place their ache specialists stated, ‘You won’t ever ever get off these ache medicines.’ It’s been an unbelievable journey and I’m an enormous advocate of it.”

Naloxone Versus Naltrexone

Naloxone (Narcan) is what’s carried on ambulances and utilized in ERs and trauma bays as an antidote to an opioid overdose. When given at a excessive sufficient dose, naloxone or Narcan acts as an entire opioid blocker, which is why it is used acutely when somebody has taken too excessive a dose of an opioid.

Naltrexone blocks the opioid receptor solely briefly, and by a special mechanism. When utilized in low dosages as LDN, the chief profit is definitely within the rebound impact, after the opioid receptor has been briefly blocked.

Foundational Treatment Strategies for Autoimmune Diseases

With regard to autoimmune illnesses, it is vital to understand there are different, equally vital, foundational methods that may profit most sufferers with a dysfunctional immune system. These embody optimizing your vitamin D degree and omega-3 index, for instance.

It’s additionally vital to remove potential triggers. The cause why individuals have an autoimmune illness is as a result of they’re uncovered to one thing within the atmosphere which serves as an antigen that their physique acknowledges as a overseas invader, and consequently assaults it. If you possibly can keep away from these antigens, you possibly can usually suppress and often remove signs with out something, since you’ve eliminated the stimulus.

One frequent autoimmune set off is lectins, discovered in lots of in any other case wholesome greens. Zielsdorf will sometimes place her autoimmune sufferers on a Mediterranean-style paleo food regimen or an oligoantigenic elimination food regimen to optimize cleansing, liver and kidney operate, and the microbiome.

Others could also be positioned on a nose-to-tail carnivore food regimen. As famous by Zielsdorf, it is “a way of offloading and simplifying what antigens the body is seeing.” Other useful diets on this respect embody the autoimmune paleo food regimen and the low-histamine or low FODMAP food regimen.4

“I am a microbiologist and I do a ton of advanced testing, and then we start looking deeper at triggers,” she says. “I used to place all people on LDN first, however now we all know that sure sufferers will aptitude as a result of their immune system is so suppressed as a consequence of co-infections.

We see it most with Lyme illness and with yeast overgrowth. If I believe or I’ve exams confirming {that a} affected person has one of these items, or their immune system is tremendous suppressed … I’ll work on their microbiome earlier than I begin LDN …

I check all people’s intestine, and what I see universally is you get this hyper intense intestinal permeability in these instances … What’s so attention-grabbing is a leaky intestine equals a leaky mind, and we overwhelm our immune system. I do see this. The first step is getting them off the most typical triggers, and typically I’ll be testing for lectins too.

Universally, for all of my autoimmune sufferers, is that they can not eat wheat. There are over 150 antigens in wheat that you would be able to be delicate to … It can also be desiccated with Roundup, glyphosate, proper earlier than processing, so we get that further toxicity. I check my sufferers for his or her environmental poisonous load, and I see so much of sufferers with glyphosate toxicity.

The wheat that we used to eat 10,000 years in the past at first of agriculture shouldn’t be the wheat [we now eat]. It’s not even the identical chromosome quantity as what our our bodies ate in small quantities as hunter gatherers.”

Why You Should Avoid Monogastric Animal Meats

As talked about by Zielsdorf, a nose-to-tail carnivore food regimen will be a wonderful intervention in some instances, particularly for these whose immune operate is severely suppressed. However, it’s best to keep away from monogastric animals, that means animals which have just one abdomen.

Whereas cows have two, chickens and pigs have just one. The cause for this advice is as a result of conventionally manufacturing unit farmed rooster and pork can be very excessive within the omega-6 fats linoleic acid. This is as a result of they’re sometimes fed corn, which is excessive on this kind of fats, and a excessive linoleic acid food regimen can metabolically devastate your well being. So, a food regimen excessive in rooster and bacon shouldn’t be doing all your physique any favors.

Animals with two stomachs are in a position to totally course of omega-6-rich grains and different meals, as they’re outfitted with intestine micro organism that may break it down right into a more healthy fats. Aside from bovines, this consists of buffalo and lamb.

What Can LDN Treat?

Aside from autoimmune illnesses, LDN can also be used within the therapy of the next circumstances. Bear in thoughts this isn’t an entire checklist. Some of these circumstances have been featured in numerous documentaries5 produced by the LDN Research Trust. You can discover hyperlinks to these documentaries within the references.

Cancer6 — Research by professor Angus George Dalgleish and his colleague Dr. Wei Lou confirmed LDN may convey most cancers cells into remission utilizing pulse dosing.7 LDN additionally works synergistically with cannabidiol (CBD), and works nicely for most cancers, autoimmunity and ache circumstances

Opioid habit, dependence and restoration8 — Using microdoses of 0.001 milligrams (1 microgram), long-term customers of opioids who’ve developed a tolerance to the drug are in a position to, over time, decrease their opioid dose and keep away from withdrawal signs because the LDN makes the opioid simpler.

For opioid dependence, the standard beginning dose is 1 microgram twice a day, which is able to enable them to decrease their opioid dose by about 60%. When the opioid is taken for ache, the LDN have to be taken 4 to 6 hours aside from the opioid with a purpose to not displace the opioid’s results

Lyme illness and its coinfections9


Small intestinal bacterial overgrowth (SIBO)

Restless leg syndrome


Dermatological points


General Dosing Guidelines

Dosing will, of course, rely on the situation being handled, however there are some basic tips that may be useful. Downloadable guides will be discovered on the LDN Research Trust web site, and can be found in a number of languages. Keep in thoughts that LDN is a drug, not one thing you should buy over-the-counter, and it’s essential to work with a educated doctor who can prescribe it and monitor your well being.

“With a basic ache situation, we might use 1.5 to three or 4.5 mg. With Hashimoto’s, we begin decrease and slower as a result of sufferers with Hashimoto’s may very well have to cut back their thyroid hormone treatment in the event that they’re on it as a result of they get discount of that irritation they usually can produce extra of their very own thyroid hormone. So, we often begin at 0.5 mg.

For sufferers with temper circumstances … 0.5 to 1 mg. There was an vital paper that got here out exhibiting LDN is a vital agent for despair, for sufferers who fail these meds or as an adjunct to antidepressants. PTSD sufferers might should go larger. There are all kinds of methods and also you simply want to seek out a physician who’s well-versed in that situation.”

More Information

The LDN Research Trust’s website is a superb useful resource for all issues LDN. It has a range of assets to information sufferers, prescribing docs and pharmacists alike. It additionally has a web page the place you possibly can find LDN-literate prescribers all over the world.

Of course, to study extra, make sure to choose up a replica of “The LDN Book, Volume Two: The Latest Research on How Low Dose Naltrexone Could Revolutionize Treatment for PTSD, Pain, IBD, Lyme Disease, Dermatologic Conditions and More,” and/or “The LDN Book: How a Little-Known Generic Drug ― Low Dose Naltrexone ― Could Revolutionize Treatment for Autoimmune Diseases, Cancer, Autism, Depression and More,” which is the primary of the 2 volumes.

Both books are also available on the LDN Research Trust website, together with movies that includes all of the docs that contributed chapters to the books. You may also try The LDN Radio Show.10 Last however not least, LDN Research Trust is a nonprofit that is dependent upon public donations, so if you need to contribute to the Trust’s LDN analysis and training efforts, please make a donation.


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