“Let’s start with a thought experiment: If an engineering design flaw exists and no one measures it, can it really injure people or kill them?” a Twitter person named Ehden writes.1 He goes on to debate an neglected facet of the COVID mRNA pictures, one thing known as “codon optimization,” which just about ensures sudden outcomes. Ehden explains:2
“Trying to inform your physique to generate proteins is tough for a lot of causes. One of them is the truth that if you attempt to run the protein information by way of ribosomes which course of that code and generate the protein, it may be very sluggish or can get caught throughout the course of.
Luckily, scientists discovered a technique to overcome this downside, by doing code substitution: as an alternative of utilizing the unique genetic code to generate the protein, they modified the letters within the code so the code can be optimized. This is called Codon Optimization.”
COVID Shots Use Codon Optimization
A codon consists of three nucleotides, and nucleotides are the constructing blocks of DNA. An August 2021 article in Nature Reviews Drug Discovery, addressed the use of codon optimization as follows:3
“The open studying body of the mRNA vaccine is essentially the most essential element as a result of it accommodates the coding sequence that’s translated into protein.
Although the open studying body is just not as malleable because the non-coding areas, it may be optimized to extend translation with out altering the protein sequence by changing not often used codons with extra ceaselessly occurring codons that encode the identical amino acid residue.
For occasion, the biopharmaceutical firm CureVac AG found that human mRNA codons not often have A or U on the third place and patented a technique that replaces A or U on the third place within the open studying body with G or C. CureVac used this optimization technique for its SARS-CoV-2 candidate CVnCoV …
Although alternative of uncommon codons is a sexy optimization technique, it should be used judiciously. This is as a result of, within the case of some proteins, the slower translation price of uncommon codons is critical for correct protein folding.
To maximize translation, the mRNA sequence usually incorporates modified nucleosides, akin to pseudouridine, N1-methylpseudouridine or different nucleoside analogues. Because all native mRNAs embody modified nucleosides, the immune system has advanced to acknowledge unmodified single-stranded RNA, which is a trademark of viral an infection.
Specifically, unmodified mRNA is acknowledged by sample recognition receptors, akin to Toll-like receptor 3 (TLR3), TLR7 and TLR8, and the retinoic acid-inducible gene I (RIGI) receptor. TLR7 and TLR8 receptors bind to guanosine- or uridine-rich areas in mRNA and set off the manufacturing of kind I interferons, akin to IFNα, that may block mRNA translation.
The use of modified nucleosides, notably modified uridine, prevents recognition by sample recognition receptors, enabling enough ranges of translation to supply prophylactic quantities of protein.
Both the Moderna and Pfizer–BioNTech SARS-CoV-2 vaccines … comprise nucleoside-modified mRNAs. Another technique to keep away from detection by sample recognition receptors, pioneered by CureVac, makes use of sequence engineering and codon optimization to deplete uridines by boosting the GC content material of the vaccine mRNA.”
Much of this information was beforehand reviewed in my interview with Stephanie Seneff, Ph.D., and Judy Mikovits, Ph.D. You can’t see the article however the video is embedded above. This research was revealed properly after our interview and merely confirms what Seneff and Mikovits have unraveled of their analysis.
According to Ehden, 60.9% of the codons in COVID pictures have been optimized, equal to 22.5% of the nucleotides, however he doesn’t specify which shot he’s speaking about, or precisely the place the information got here from.
That all mRNA COVID pictures are utilizing codon optimization to 1 diploma or one other is obvious, nonetheless. A July 2021 article4 within the journal Vaccines particularly evaluates and feedback on the Pfizer/BioNTech and Moderna mRNA pictures, noting:
“The design of Pfizer/BioNTech and Moderna mRNA vaccines entails many differing types of optimizations … The mRNA elements of the vaccine must have a 5′-UTR to load ribosomes effectively onto the mRNA for translation initiation, optimized codon utilization for environment friendly translation elongation, and optimum cease codon for environment friendly translation termination.
Both 5′-UTR and the downstream 3′-UTR ought to be optimized for mRNA stability. The alternative of uridine by N1-methylpseudourinine (Ψ) complicates some of these optimization processes as a result of Ψ is extra versatile in wobbling than U. Different optimizations can battle with one another, and compromises would have to be made.
I spotlight the similarities and variations between Pfizer/BioNTech and Moderna mRNA vaccines and talk about the benefit and drawback of every to facilitate future vaccine enchancment. In specific, I level out a couple of optimizations within the design of the 2 mRNA vaccines that haven’t been carried out correctly.”
What Can Go Wrong?
One key take-home from the Nature Reviews Drug Discovery article5 cited above is that changing uncommon codons “must be used judiciously,” as rarer codons can have slower translation charges and a slowed-down price is definitely mandatory to stop protein misfolding.
A (adenine) and U (uracil) within the third place are uncommon, and the COVID pictures exchange these A’s and U’s with G’s (guanine) or C’s (cytosine). According to Seneff, this change leads to a 1,000-fold better quantity of spike protein in comparison with being contaminated with the precise virus.
What may go mistaken? Well, absolutely anything. Again, the shot induces spike protein at ranges unheard of in nature (even when SARS-CoV-2 is a “souped up” artifical concoction), and the spike protein is the poisonous half of the virus liable for essentially the most distinctive results of the virus, such because the blood clotting issues, neurological issues and coronary heart harm.
So, to count on the COVID shot to not produce these varieties of results can be quite naïve. The codon switches may additionally lead to protein misfolding, which is equally unhealthy information. As defined by Seneff in our earlier interview:
“The spike proteins that these mRNA vaccines are producing … aren’t in a position to enter the membrane, which I believe goes to encourage it to develop into a problematic prion protein. Then, when you’ve got irritation, it upregulates alpha-synuclein [a neuronal protein that regulates synaptic traffic and neurotransmitter release].
So, you are going to get alpha-synuclein drawn into misfolded spike proteins, turning into a large number contained in the dendritic cells within the germinal facilities within the spleen. And they are going to package deal up all this crud into exosomes and launch them. They’re then going to journey alongside the vagus nerve to the brainstem and trigger issues like Parkinson’s illness.
So, I believe it is a full setup for Parkinson’s illness … It’s going to push ahead the date at which somebody who has a propensity in the direction of Parkinson’s goes to get it.
And it is most likely going to trigger folks to get Parkinson’s who by no means would have gotten it within the first place — particularly in the event that they preserve getting the vaccine yearly. Every yr you do a booster, you convey the date that you’ll get Parkinson’s ever nearer.”
Immune Dysfunction and Viral Flare-Ups
Other important threats embody immune dysfunction and the flare-up of latent viral infections, which is one thing Mikovits has been warning about. In our earlier interview, she famous:
“We use poly(I:C) [a toll-like receptor 3 agonist] to sign the cell to activate the sort I interferon pathway, and since [the spike protein your body produces in response to the COVID shot] is an unnatural artificial envelope, you are not seeing poly(I:C), and you are not [activating] the Type I interferon pathway.
You’ve bypassed the plasmacytoid dendritic cell, which mixed with IL-10, by speaking to the regulatory B cells, decides what subclasses of antibodies to place out. So, you’ve got bypassed the communication between the innate and adaptive immune response. You now miss the signaling of the endocannabinoid receptors …
A big half of Dr. [Francis] Ruscetti’s and my work over the past 30 years has been to indicate you do not want an infectious transmissible virus — simply items and components of these viruses are worse, as a result of in addition they activate hazard indicators. They act like hazard indicators and pathogen-associated molecular patterns.
So, it synergistically leaves that inflammatory cytokine signature on that spins your innate immune response out of management. It simply can’t sustain with the myelopoiesis [the production of cells in your bone marrow]. Hence you see a skew-away from the mesenchymal stem cell in the direction of TGF-beta regulated hematopoietic stem cells.
This means you would see bleeding issues on each ends. You cannot make sufficient firetrucks to ship to the fireplace. Your innate immune response cannot get there, and then you definitely’ve simply bought a complete practice wreck of your immune system.”
We’re now seeing stories of herpes and shingles an infection following COVID-19 injection, and that is exactly what you’ll be able to count on in case your Type I interferon pathway is disabled. That’s not the top of your potential troubles, nonetheless, as these coinfections may speed up different illnesses as properly.
For instance, herpes viruses have been implicated as a set off of each AIDS6 and myalgic encephalomyelitis7 (persistent fatigue syndrome or ME-CFS). According to Mikovits, these illnesses don’t seem till viruses from completely different households companion up and retroviruses take out the Type 1 interferon pathway. Long time period, the COVID mass injection marketing campaign could also be laying the muse for a quickly approaching avalanche of a variety of debilitating persistent diseases.
Are COVID Shots Appropriately Optimized?
As famous within the Vaccines article cited earlier, the codon optimization within the Pfizer and Moderna pictures could possibly be problematic:8
“As mammalian host cells assault unmodified exogeneous RNA, all U nucleotides had been changed by N1-methylpseudouridine (Ψ). However, Ψ wobbles extra in base-pairing than U and might pair not solely with A and G, but in addition, to a lesser extent, with C and U.
This is more likely to enhance misreading of a codon by a near-cognate tRNA. When nucleotide U in cease codons was changed by Ψ, the speed of misreading of a cease codon by a near-cognate tRNAs elevated.
Such readthrough occasions wouldn’t solely lower the quantity of immunogenic proteins, but in addition produce an extended protein of unknown destiny with doubtlessly deleterious results …
The designers of each vaccines thought of CGG because the optimum codon within the CGN codon household and recoded virtually all CGN codons to CGG … [M]ultiple strains of proof recommend that CGC is a greater codon than CGG. The designers of the mRNA vaccines (particularly mRNA-1273) selected a mistaken codon because the optimum codon.”
The paper additionally factors out the significance of vaccine mRNA to be translated precisely and never merely successfully, as a result of if the mistaken amino acids are integrated, it might confuse your immune system and stop it from figuring out the proper targets.
Accuracy can be essential in translation termination, and right here it comes right down to choosing the proper cease codons. Stop codons (UAA, UAG or UGA), when current on the finish of an mRNA coding sequence indicators the termination of protein synthesis.
According to the writer, each Pfizer and Moderna chosen lower than optimum cease codons. “UGA is a poor choice of a stop codon, and UGAU in Pfizer/BioNTech and Moderna mRNA vaccines could be even worse,” she says.
What Health Problems Can We Expect to See More Of?
While the variability of illnesses we may even see an increase in in consequence of this vaccination marketing campaign are myriad, some basic predictions could be made. We’ve already seen a large uptick in blood clotting issues, coronary heart assaults and stroke, in addition to coronary heart irritation.
More long run, Seneff believes we’ll see a major rise in most cancers, accelerated Parkinson’s-like illnesses, Huntington’s illness, and every kind of autoimmune illnesses and neurodegenerative issues.
Mikovits additionally suspects many will develop persistent and debilitating illnesses and can die prematurely. At highest threat, she locations those that are asymptomatically contaminated with XMRVs and gammaretroviruses from contaminated typical vaccines. The COVID shot will successfully speed up their dying by crippling their immune perform. “The kids that are highly vaccinated, they’re ticking time bombs,” Mikovits stated in my May 2021 interview.
What Are the Options?
While all of that is extremely problematic, there’s hope. From my perspective, I consider one of the best factor you are able to do is to construct your innate immune system. To try this, it’s good to develop into metabolically versatile and optimize your weight-reduction plan. You’ll additionally wish to ensure your vitamin D degree is optimized to between 60 ng/mL and 80 ng/mL (100 nmol/L to 150 nmol/L).
I additionally advocate time-restricted consuming, the place you eat all of your meals for the day inside a six- to eight-hour window. Time-restricted consuming can even upregulate autophagy, which can assist digest and take away spike protein. Avoid all vegetable oils and processed meals. Focus on certified-organic meals to reduce your glyphosate publicity.
Sauna remedy may be useful. It upregulates warmth shock proteins, which might help refold misfolded proteins. They additionally tag broken proteins and goal them for elimination.