Don’t Use Antibody Tests Post Vaccine to Determine Immunity

Antibodies are proteins your physique makes in response to infections and shall be detectable in your blood after an infection as an indication of your physique’s battle in opposition to that pathogen. Antibodies for COVID-19 are believed to develop inside one to three weeks after an infection, and a constructive antibody check for COVID-19 implies that an individual might have been contaminated with SARS-CoV-2, the virus that causes COVID-19, up to now.1

Titer blood checks, which measure the presence and quantities of sure antibodies in your blood, are typically used to show immunity to a illness.2 If your titer is constructive, which suggests it’s above a set worth, you’re thought of to be immune to the illness, comparable to measles, mumps or rubella.3

This is why, as an illustration, proof of prior prognosis with chickenpox, measles and mumps is allowed as a substitute of vaccination to enter most U.S. public colleges4 — when you’ve had the illness and recovered, you’re immune.

In the case of COVID-19, nonetheless, the U.S. Food and Drug Administration issued a security communication in May 2021,5 warning each the general public and well being care suppliers not to use SARS-CoV-2 antibody checks to gauge immunity, particularly amongst individuals who’ve acquired a COVID-19 vaccine.

Antibody Testing Not Recommended to Assess COVID-19 Immunity

In their security communication, the FDA famous, “… results from currently authorized SARS-CoV-2 antibody tests should not be used to evaluate a person’s level of immunity or protection from COVID-19 at any time, and especially after the person received a COVID-19 vaccination.”

They state that whereas a constructive antibody check might establish those that have been beforehand contaminated with SARS-CoV-2, “more research is needed in people who have received a COVID-19 vaccination.” SARS-CoV-2 antibody checks haven’t been studied to assess the extent of safety the vaccine-induced immune response offers in those that’ve acquired a COVID-19 vaccine.

Even in individuals who haven’t been vaccinated, the FDA states {that a} constructive antibody check isn’t satisfactory to present that you simply’re shielded from COVID-19; it’s solely a sign that you simply had been presumably contaminated with SARS-CoV-2 beforehand. In those that have acquired a COVID-19 vaccine, a constructive consequence from a SARS-CoV-2 antibody check may point out a earlier pure an infection or could possibly be brought on by the vaccine. According to the FDA:6

“A COVID-19 vaccination may also cause a positive antibody test result for some but not all antibody tests. You should not interpret the results of your SARS-CoV-2 antibody test as an indication of a specific level of immunity or protection from SARS-CoV-2 infection.”

COVID Vaccines Induce Antibodies to the Spike Protein

There’s a big distinction within the immune response triggered by pure an infection versus vaccination. In the case of COVID-19 mRNA vaccines, comparable to these produced by Pfizer and Moderna, antibodies to the spike protein are induced. In the case of pure SARS-CoV-2 an infection, nucleocapsid proteins are detected by antibody testing.

Because of this, individuals who have acquired a COVID-19 vaccine and haven’t beforehand been contaminated will obtain a adverse antibody check, offered the check doesn’t detect the vaccine-induced spike protein antibodies.7 Interestingly, it’s been discovered that the spike proteins can injury human cells and alter mitochondrial perform even with out a viral part.8

In an animal research revealed in Circulation Research, when a pseudo virus, which was a cell surrounded by spike proteins that didn’t comprise a virus, was administered into the lungs of hamsters, it induced irritation, and when wholesome endothelial cells that line human arteries had been uncovered, it disrupted signaling to the mitochondria and induced injury and fragmentation.9

The excellent news in regards to the FDA’s warning is that, as Daily Mail put it, “the [antibody] blood test likely won’t confirm that someone has been vaccinated (functioning like a pseudo-immunity passport).”10 On the opposite hand, the warning additionally means that those that have beforehand had a constructive antibody check for COVID-19 shouldn’t assume they’re protected. However, this could possibly be a fear-based technique to persuade extra individuals to get vaccinated. Daily Mail reported:11

“The briefing comes as the United States’ vaccine rollout progress has slowed down in recent weeks, and some who have previously tested positive for COVID-19 or the antibodies do not believe getting vaccinated is necessary. The FDA is saying otherwise and encouraging all Americans to get vaccinated if they are able to do so.”

Red Cross Needs COVID Plasma — however Only From the Unvaccinated

In the U.S., greater than 100,000 individuals have been handled with COVID-19 convalescent plasma, which is usually referred to as survivor’s plasma.12 Because it incorporates antibodies to SARS-CoV-2, convalescent plasma might assist your physique battle off the virus and has been discovered to cut back the development of COVID-19 in mildly sick older adults.13

Transfusion of plasma with larger SARS-CoV-2 antibody ranges has additionally been linked to a decrease danger of dying in nonventilated sufferers hospitalized for COVID-19, in contrast to transfusion of plasma with decrease antibody ranges.14 The Red Cross accepts donations for COVID-19 convalescent plasma, however solely from individuals who haven’t acquired a COVID-19 vaccine.

According to the Red Cross, “At this time individuals who have received a COVID-19 vaccine are not able to donate convalescent plasma with the Red Cross. The Red Cross is working as quickly as possible to evaluate this change — as it may involve complex system updates.”15

In a video posted to Twitter by Musicman, a information anchor states, “That [convalescent] plasma is made up of antibodies from people who have recovered from the virus, but the vaccine wipes out those antibodies, making the convalescent plasma ineffective in treating other COVID-19 patients.”16

While the Red Cross web site doesn’t clarify why they’re “not able” to use convalescent plasma, in January 2021 the Regulatory Affairs Professionals Society (RAPS) supplied a clue to its membership after the FDA revised its pointers on who can qualify to donate.

“With two vaccines authorized for emergency use in the U.S. and others in clinical development, FDA says that convalescent plasma should not be collected from individuals who received an investigational COVID-19 vaccine in a clinical trial or who received an authorized or licensed COVID-19 vaccine, unless they meet specific criteria detailed in the guidance,” RAPS says.17

In order to be eligible, the FDA acknowledged vaccine recipients will need to have had signs of COVID-19 together with a positive test consequence, and be inside six months of full decision of signs. According to the FDA, the aim of the factors is “to ensure the COVID-19 convalescent plasma collected from donors contains sufficient antibodies directly related to their immune response to COVID-19 infection.”18

Before the COVID-19 vaccines acquired emergency use authorization, the FDA additionally warned in opposition to gathering convalescent plasma from topics who acquired the vaccine in a medical trial “because of the uncertainty regarding the quality of the immune response produced by such investigational vaccines.”19

Problems With Antibody Tests

There have been issues with COVID-19 antibody checks from the beginning, partly as a result of it could flip constructive you probably have antibodies in opposition to frequent chilly viruses. There are seven totally different coronaviruses that trigger respiratory sickness in people. Four of them trigger signs related to the frequent chilly, whereas three of them — SARS-CoV, MERS-CoV and SARS-CoV-2 — could cause extra critical respiratory sickness.

However, the antibodies created by these coronaviruses are very comparable, and the U.S. CDC admitted that recovering from the common cold can trigger a positive antibody test for COVID-19, even for those who had been by no means contaminated with SARS-CoV-2 particularly. According to the CDC:20

“A positive test result shows you may have antibodies from an infection with the virus that causes COVID-19. However, there is a chance that a positive result means you have antibodies from an infection with a different virus from the same family of viruses (called coronaviruses).”

Vaccine Risks for People Who’ve Had COVID

An worldwide survey of two,002 individuals who had acquired a primary dose of COVID-19 vaccine discovered that individuals who had beforehand had COVID-19 skilled “significantly increased incidence and severity” of side effects after the COVID-19 vaccine.21 Those who had beforehand had COVID-19 had a higher danger of experiencing any aspect impact, together with the next, particularly:



Flu-like sickness


Local reactions

Severe unintended effects main to hospital care

The mRNA COVID-19 vaccines had been linked to the next incidence of unintended effects in contrast to the viral vector-based COVID-19 vaccines, however the mRNA unintended effects tended to be milder, native reactions. Systemic reactions, comparable to anaphylaxis, flu-like sickness and breathlessness, had been extra possible to happen with the viral vector COVID-19 vaccines.

According to the researchers, the findings ought to immediate well being officers to re-evaluate their vaccination suggestions for individuals who’ve had COVID-19,22 however the CDC continues to state that those that have recovered from COVID-19 ought to nonetheless get vaccinated.23

Dr. Hooman Noorchashm, Ph.D., has repeatedly warned the FDA that “clear and present danger” exists for many who have had COVID-19 and subsequently get vaccinated, due to viral antigens that stay within the physique after an individual is of course contaminated; the immune response reactivated by the COVID-19 vaccine might set off irritation in tissues the place the viral antigens exist.24

Noorchashm believes that individuals needs to be screened for SARS-CoV-2 viral proteins prior to COVID-19 vaccination, whereas vaccination needs to be delayed for individuals with symptomatic or asymptomatic COVID-19 infections, in addition to for many who have lately recovered from the virus.

Booster Dose Within One Year of COVID Vaccine?

The media proceed to promote the faux narrative that pure immunity — the kind acquired by getting contaminated by and recovering from a virus — isn’t as highly effective or long-lasting as vaccine-acquired immunity.25,26

However, Dr. Anthony Fauci acknowledged throughout an Axios digital occasion {that a} COVID-19 vaccine booster is probably going. “I think we will almost certainly require a booster sometime within a year or so, after getting the primary [shot],” he said, “because the durability of protection against coronaviruses is generally not lifelong.”27

Pfizer’s CEO Albert Bourla has additionally acknowledged that not solely will individuals want a 3rd booster dose of COVID-19 vaccine inside 12 months of being totally vaccinated, however annual vaccination will most likely be obligatory.28

Robust pure immunity has been demonstrated, nonetheless, for a minimum of eight months after an infection in additional than 95% of people that have recovered from COVID-19.29,30 A Nature research additionally demonstrated strong pure immunity in individuals who recovered from SARS and SARS-CoV-2,31 whereas extra knowledge present sufferers who had been contaminated with COVID-19 develop an immune response that might defend them for years.32


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