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COVID-19 vaccines not linked to pregnancy loss; mixing vaccines may confer greater protection By Reuters

© Reuters. Michelle Melton, who’s 35 weeks pregnant, receives the Pfizer-BioNTech vaccine in opposition to the coronavirus illness (COVID-19) at Skippack Pharmacy in Schwenksville, Pennsylvania, U.S., February 11, 2021. REUTERS/Hannah Beier/File Photo

By Nancy Lapid

(Reuters) – The following is a abstract of some current research on COVID-19. They embrace analysis that warrants additional examine to corroborate the findings and which have but to be licensed by peer evaluate.

COVID-19 vaccines not linked with pregnancy loss

Two research in main medical journals add to proof that COVID-19 vaccines are secure earlier than and through pregnancy. One examine, printed in The New England Journal of Medicine on Wednesday, tracked practically 18,500 pregnant ladies in Norway, together with about 4,500 who had miscarriages. Researchers discovered no hyperlink between COVID-19 vaccines and threat of first-trimester miscarriage, no matter whether or not the vaccines had been from Moderna (NASDAQ:), Pfizer (NYSE:) and BioNTech, or AstraZeneca (NASDAQ:). Overall, the ladies with miscarriages had been 9% much less doubtless to have been vaccinated, in accordance to the researchers’ calculations. In a separate examine printed on Thursday in The Lancet, researchers tracked 107 ladies who grew to become pregnant whereas taking part in trials of AstraZeneca’s vaccine within the UK, Brazil and South Africa. Seventy-two of the ladies had acquired the vaccine whereas the others received a placebo. AstraZeneca’s vaccine had no impact on the percentages of safely carrying the pregnancy to time period, the researchers reported. “It is important that pregnant women are vaccinated since they have a higher risk of hospitalizations and COVID-19-complications, and their infants are at higher risk of being born too early,” the authors of the Norwegian examine wrote. “Also, vaccination during pregnancy is likely to provide protection to the newborn infant against COVID-19 infection in the first months after birth.”

Vaccine mixtures with totally different applied sciences may be finest

Healthcare staff in France who received a primary shot of AstraZeneca’s COVID-19 vaccine after which the Pfizer/BioNTech vaccine for his or her second shot confirmed stronger immune responses than those that had acquired two photographs of the Pfizer vaccine, in a current examine. Combining totally different applied sciences is thought to increase immune responses to different viruses, and the present examine suggests it may be true for the coronavirus as nicely. Both vaccines within the examine ship directions that train cells within the physique to make a chunk of protein that resembles the spike on the coronavirus and that triggers an immune response. But they do it in very other ways. Both protocols offered “safe and efficient” protection, mentioned Vincent Legros of Universite de Lyon in France, coauthor of a report printed on Thursday in Nature. But combining the AstraZeneca shot with the Pfizer/BioNTech vaccine “conferred even better protection” than two doses of Pfizer’s shot, together with in opposition to the Delta variant, Legros mentioned. The two applied sciences mixed induced an antibody response of higher high quality, with extra neutralizing antibodies that would block the virus, and extra cells which were “trained” by the vaccine to have elevated protection potential, he mentioned. Combination vaccination “is safe and may provide interesting options… for clinicians to prevent SARS-CoV-2 infection,” Legros concluded.

Cognitive issues seen in middle-aged COVID-19 survivors

A “substantial proportion” of middle-aged COVID-19 survivors with no earlier dementia had cognitive issues greater than half a 12 months after analysis, researchers have discovered. They checked out 740 individuals who ranged in age from 38 to 59. About half had been white, and 63% had been feminine. On checks of pondering expertise, 20% had bother changing short-term reminiscences to long-term reminiscences, 18% had bother processing information quickly, and 16% had bother with expertise wanted for planning, focusing consideration, remembering directions, and juggling a number of duties. The common time from analysis was 7.6 months. About one-in-four sufferers had been hospitalized, however most of them had been not critically sick. “We can’t exactly say that the cognitive issues were lasting because we can’t determine when they began,” mentioned Dr. Jacqueline Becker of the Icahn School of Medicine at Mount Sinai in New York City, who co-led the examine printed on Friday in JAMA Network Open. “But we can say that our cohort had higher than anticipated frequency of cognitive impairment” on condition that they had been comparatively younger and wholesome, Becker mentioned.

Data assist use of Pfizer vaccine in kids and teenagers

The Pfizer/BioNTech COVID-19 vaccine confirmed 90.7% efficacy in opposition to the coronavirus in a trial of youngsters ages 5 to 11, the U.S. drugmaker mentioned on Friday in briefing paperwork submitted to the U.S. Food and Drug Administration however not formally printed. The kids got two photographs of a 10-microgram dose of the vaccine – a 3rd of the energy given to individuals 12 and older. The examine was not primarily designed to measure efficacy in opposition to the virus. Instead, it in contrast the quantity of neutralizing antibodies induced by the vaccine within the kids to the response of recipients of their grownup trial. Pfizer and BioNTech mentioned the vaccine induced a strong immune response within the kids. Outside advisers to the FDA are scheduled to meet on Tuesday to vote on whether or not to advocate authorization of the vaccine for that age group. A separate examine from Israel carried out whereas the Delta variant was prevalent and printed on Wednesday in The New England Journal of Medicine, in contrast practically 95,000 12- to -18-year-olds who had acquired Pfizer’s vaccine with an equal variety of adolescents who had not been vaccinated. The outcomes present the vaccine “was highly effective in the first few weeks after vaccination against both documented infection and symptomatic COVID-19 with the Delta variant” on this age group, the analysis workforce reported.

Click for a Reuters graphic on vaccines in growth.

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